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GENETIC ABNORMALITY MAY EXPLAIN HIGH RATES OF HEART DISEASE IN ASIAN INDIAN POPULATION
As a group, Asian Indians have one of the highest rates of heart disease in
the world, three times higher than in the United States. In spite of a fairly
healthy lifestyle, many Asian Indians have very high levels of the blood fat
triglyceride and low levels of HDL (the good cholesterol), as well as a high incidence of diabetes. Researchers have been trying to figure out why the group is at higher risk.
Now, a University of Maryland Medical Center study provides evidence that a genetic abnormality could explain the difference. The study results were presented on November 8 at the 72nd Annual Scientific Sessions of the American Heart Association in Atlanta, Georgia. "We found that a genetic abnormality in triglyceride regulation appears to be common among Asian Indians," says Michael Miller, M.D., director,Center for Preventive Cardiology at the University of Maryland Medical Center and principle investigator of the study.
"We think this abnormality prevents blood fats from being broken down effectively and, as a result, triglyceride levels may accumulate to dangerously high levels," says Dr. Miller, who is also an associate professor ofMedicine at the University of Maryland School of Medicine. For the study, Dr. Miller analyzed blood samples and DNA from 100 people of Asian Indian decent who had gathered at an Indian festival in Northern Virginia and volunteered to have their blood drawn. The vast majority of the
people tested, 70 percent, had the same genetic abnormality intriglyceride
regulation, placing them at increased risk of heart disease.
Triglyceride is a type of fat that is always circulating in the blood, especially after a meal high in saturated fat. Usually, triglyceride particles are broken down by enzymes. When that process is not working
efficiently, the triglycerides that are only partially broken down can cause fatty deposits in blood vessels, leading to atherosclerosis, known as hardening of the arteries.
Triglycerides have also been shown to increase the risk of bloodclots,which
combine with fatty deposits in the coronary vessels to cause heartattacks.
Previous work by Dr. Miller and his research team demonstrated that triglyceride levels above 100 mg/dL increase the risk of heartdisease. The average triglyceride level among the Asian Indians in this study who had the genetic abnormality was approximately 350 mg/dL. In addition, 33percent had a family history of heart disease and 20 percent had diabetes.
Studies have shown that the genetic abnormality found to be prevalent inthis
Asian Indian population is also involved with insulin regulation. That might
explain the high rates of diabetes observed in this population.
Other members of Dr. Miller's team include Jeffrey Rhyne, M.S, and Meena Khatta, R.N., at the University of Maryland Medical Center, KarenZeller, M.S. at The Johns Hopkins Hospital and Hemal Parekh, M.D. at Stanford University Medical Center.

GENETIC ABNORMALITY MAY EXPLAIN HIGH RATES OF HEART DISEASE IN ASIAN INDIAN POPULATION
As a group, Asian Indians have one of the highest rates of heart disease in
the world, three times higher than in the United States. In spite of a fairly
healthy lifestyle, many Asian Indians have very high levels of the blood fat
triglyceride and low levels of HDL (the good cholesterol), as well as a high incidence of diabetes. Researchers have been trying to figure out why the group is at higher risk.
Now, a University of Maryland Medical Center study provides evidence that a genetic abnormality could explain the difference. The study results were presented on November 8 at the 72nd Annual Scientific Sessions of the American Heart Association in Atlanta, Georgia. "We found that a genetic abnormality in triglyceride regulation appears to be common among Asian Indians," says Michael Miller, M.D., director,Center for Preventive Cardiology at the University of Maryland Medical Center and principle investigator of the study.
"We think this abnormality prevents blood fats from being broken down effectively and, as a result, triglyceride levels may accumulate to dangerously high levels," says Dr. Miller, who is also an associate professor ofMedicine at the University of Maryland School of Medicine. For the study, Dr. Miller analyzed blood samples and DNA from 100 people of Asian Indian decent who had gathered at an Indian festival in Northern Virginia and volunteered to have their blood drawn. The vast majority of the
people tested, 70 percent, had the same genetic abnormality intriglyceride
regulation, placing them at increased risk of heart disease.
Triglyceride is a type of fat that is always circulating in the blood, especially after a meal high in saturated fat. Usually, triglyceride particles are broken down by enzymes. When that process is not working
efficiently, the triglycerides that are only partially broken down can cause fatty deposits in blood vessels, leading to atherosclerosis, known as hardening of the arteries.
Triglycerides have also been shown to increase the risk of bloodclots,which
combine with fatty deposits in the coronary vessels to cause heartattacks.
Previous work by Dr. Miller and his research team demonstrated that triglyceride levels above 100 mg/dL increase the risk of heartdisease. The average triglyceride level among the Asian Indians in this study who had the genetic abnormality was approximately 350 mg/dL. In addition, 33percent had a family history of heart disease and 20 percent had diabetes.
Studies have shown that the genetic abnormality found to be prevalent inthis
Asian Indian population is also involved with insulin regulation. That might
explain the high rates of diabetes observed in this population.
Other members of Dr. Miller's team include Jeffrey Rhyne, M.S, and Meena Khatta, R.N., at the University of Maryland Medical Center, KarenZeller, M.S. at The Johns Hopkins Hospital and Hemal Parekh, M.D. at Stanford University Medical Center.
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